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Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma
I Takanami1, T Imamura, T Hashizume
1Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.
Journal of Clinical Pathology
|December 1, 1994
Abstract
Aims:
To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma.
Methods:
TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients.
Results:
Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group.
Conclusions:
TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.