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Related Experiment Videos

Reflex epilepsies: experience in Sri Lanka

N Senanayake1

  • 1Department of Medicine, Faculty of Medicine, University of Peradeniya, Sri Lanka.

The Ceylon Medical Journal
|June 1, 1994
PubMed
Summary

Reflex epilepsy, often triggered by eating, affects 17.3% of patients. Eating epilepsy is common, particularly in males, with seizures possibly linked to amygdala stimulation. Clobazam showed promise in managing reflex epilepsies.

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Area of Science:

  • Neurology
  • Epileptology

Background:

  • Reflex epilepsy (RE) involves seizures triggered by specific stimuli.
  • Eating epilepsy (EE) and photosensitive epilepsy (PSE) are subtypes of RE.
  • Understanding triggers and mechanisms is crucial for managing RE.

Purpose of the Study:

  • To investigate the prevalence and characteristics of reflex epilepsy in a patient cohort.
  • To explore potential mechanisms underlying different types of reflex epilepsy.
  • To evaluate management strategies and seizure-inhibitory mechanisms for RE.

Main Methods:

  • Prospective study of 1287 epileptic patients.
  • Analysis of seizure triggers, patient demographics, and seizure types.
  • Evaluation of intermittent photic stimulation and response to clobazam treatment.

Main Results:

  • 17.3% of patients had RE, with eating as the most common trigger (85.7%).
  • Photosensitive epilepsy (PSE) was rare (6.9% positive photoconvulsive response).
  • Eating epilepsy (EE) was male-predominant, with onset in the second decade and partial complex seizures.

Conclusions:

  • Eating epilepsy is the most prevalent form of RE in this cohort.
  • Repetitive amygdala stimulation is a proposed mechanism for EE.
  • Clobazam demonstrated effectiveness in managing RE, and mediation warrants further investigation for seizure control.

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