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Quinine and quinidine photoproducts can be identical
M Isaksson1, M Bruze, B Gruvberger
1Department of Dermatology, Lund University, Sweden.
Acta Dermato-Venereologica
|July 1, 1994
Summary
Quinine and quinidine can cause allergic reactions. This study found that UV exposure creates identical photoproducts from both quinine and quinidine, explaining their cross-reactivity in photoallergic reactions.
Area of Science:
- Photodermatology
- Chemical analysis
- Allergenicity
Background:
- Quinine and quinidine can induce contact allergy and photoallergy.
- Clinical observations suggest cross-reactivity between quinine and quinidine in photoallergic reactions, but not typically in contact allergies.
Purpose of the Study:
- To investigate the potential formation of common photoproducts from quinine and quinidine upon UV exposure.
- To elucidate the mechanism behind the differing cross-reactivity patterns observed in contact versus photoallergic sensitization.
Main Methods:
- Solutions of quinine and quinidine (0.1% in ethanol) were irradiated with UVA light.
- Photoproducts were analyzed using thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC).
Main Results:
- Irradiated quinine yielded 8 photoproducts, and irradiated quinidine yielded 6 photoproducts via TLC.
- Five photoproducts were common to both irradiated quinine and quinidine chromatograms.
- HPLC analysis revealed an identical pattern of four photoproducts for both irradiated solutions.
Conclusions:
- UV-irradiated quinine and quinidine can generate identical sensitizing photoproducts.
- The formation of common photoproducts explains the observed cross-reactivity in photoallergic reactions between these two isomers.