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Updated: Jul 28, 2026

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Published on: September 28, 2015
[Pressure build-up in 2 rate-controlled syringe infusion pumps]
1Kolding Sygehus, anaestesiafdelingen.
Abstract:
The use of rate controlled syringe infusion pumps has spread to departments where the need for accurate infusion exists. The simplicity in using these pumps has led to a false feeling of safety. A case of hazardous use of a syringe infusion pump has been reviewed. An Ohmeda 9000- and a Terumo STC 521 syringe pump was here tested, n = 20. The occlusion pressures of the two pumps were different. The occlusion pressure changed with different infusion rates for both pumps. The pressure was built up in a straight linear fashion. The bolus release depended on the occlusion pressure and the amounts given were in the range of 1.0-1.6 ml, both pumps included. The time from occlusion to alarm depended on the occlusion pressures. There might be an advantage in using a soft infusion system. It is recommended not to use syringe pump infusion via peripheral veins so as to avoid the risk of pressure build-up in the subcutaneous tissue in case of infiltration. In the event of occlusion disconnect the infusion system prior to reopening. Don't rely on the occlusion alarm. Use a smooth infusion system.
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