[Deformation of tablets according to breaking hardness]

The authors were the first to test the breaking process of tablets in home respect. In experiments on the breaking of tablets a tablet hardness tester developed by the Chemical and Pharmaceutical Works Ltd. Chinoin (Budapest) was used. With an appropriate program, this permitted not only a qualitative evaluation of the breaking curves (Fig. 2-4.) also an assessment of the breaking work relating to the breaking strength and even the work needed for various deformation processes (Tab. I-II.). The concept of the breaking factor was introduced: this allows a differentiation of tablets even if the breaking strengths are the same (see Tab. III. 1-2 tablets; with two samples analysis; p < 0.05.) It is concluded that such breaking strength examinations contribute to a better understanding of the behaviour of substances during compression. These results can be very useful both in preformulation examinations and in tests on the prepared products.