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Keratoprosthesis in end-stage dry eye
1Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute, Harvard Medical School, Boston 02114.
Advances in Experimental Medicine and Biology
|January 1, 1994
Summary
Keratoprosthesis surgery offers vision restoration for severe dry eye patients. Three of five patients with end-stage dry eye achieved good vision after this complex procedure.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- End-stage dry eye significantly impairs vision.
- Severe dry eye can result from conditions like pemphigoid and Stevens-Johnson syndrome.
- Keratoprosthesis is a surgical option for eyes unresponsive to conventional treatments.
Purpose of the Study:
- To evaluate the outcomes of keratoprosthesis implantation in patients with end-stage dry eye.
- To assess the efficacy and safety of keratoprosthesis in complex ocular surface diseases.
Main Methods:
- Retrospective case series of five patients with end-stage dry eye.
- Patients underwent keratoprosthesis surgery.
- Follow-up duration ranged from 6 to 22 months.
Main Results:
- Two cases (40%) were considered surgical failures.
- Three cases (60%) maintained good vision post-surgery.
- The study included patients with pemphigoid and Stevens-Johnson syndrome.
Conclusions:
- Keratoprosthesis implantation can restore vision in select patients with end-stage dry eye.
- Outcomes are variable, with a significant proportion experiencing success.
- Further research is needed to optimize patient selection and surgical techniques.