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Decrease in the airways' nonadrenergic noncholinergic inhibitory system in allergen sensitized rabbits

T M Fame, G N Colasurdo, J E Loader

    Pediatric Pulmonology
    |May 1, 1994
    PubMed
    Summary
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    Allergen exposure significantly impairs the airways' nonadrenergic noncholinergic inhibitory (NANC-i) system in rabbits, reducing neural relaxation responses. This dysfunction in the NANC-i system is linked to allergen-induced neural control changes in the airways.

    Area of Science:

    • Pulmonary Physiology
    • Immunology
    • Neuroscience

    Background:

    • Allergen exposure can alter neural control of airways.
    • The nonadrenergic noncholinergic inhibitory (NANC-i) system plays a role in airway function.

    Purpose of the Study:

    • To investigate the impact of allergen sensitization and challenge on NANC-i responses in rabbit airways.
    • To determine if allergen-induced changes affect neural contractile and relaxant mechanisms.

    Main Methods:

    • Rabbit models: control, ragweed-sensitized (immune), and ragweed-challenged (immune challenged).
    • Electrical field stimulation (EFS) used to measure neurally mediated contractile and NANC-i relaxant responses in tracheal and left mainstem bronchus (LMB) segments.
    • NANC-i responses assessed after contraction with neurokinin A (NKA) in the presence of atropine and propranolol.

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    Main Results:

    • Neurally mediated contractile responses to EFS increased in immune-challenged rabbits, particularly in tracheal smooth muscle at 20 Hz.
    • No significant differences in contractile responses to NKA were observed among groups.
    • Tracheal segments showed significantly reduced NANC-i relaxation: control (29.1%), immune (15.8%), and immune challenged (2.1%).

    Conclusions:

    • Allergen challenge significantly diminishes the NANC-i relaxant function in rabbit airways.
    • Impaired NANC-i function may contribute to altered neural control observed in allergic airway responses.
    • These findings highlight a potential mechanism underlying airway dysfunction in allergic conditions.