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[Anticardiolipin syndrome with only skin involvement]
S Bühler-Singer1, J von Hintzenstern, M Fartasch
1Dermatologische Klinik und Poliklinik, Universität Erlangen-Nürnberg.
Summary
Anticardiolipin syndrome (ACS) can manifest solely through severe skin ulcers and livedo racemosa. This case highlights successful treatment with immunosuppressants and aspirin, leading to healing without recurrence.
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Anticardiolipin syndrome (ACS) is characterized by antibodies linked to thrombosis and hematologic issues.
- Commonly associated symptoms include recurrent abortion, cerebral ischemia, and various skin disorders.
Observation:
- A 29-year-old female presented with painful, necrotic leg ulcers and livedo racemosa on her arms.
- This presentation was a rare instance of ACS manifesting exclusively through cutaneous symptoms, without identifiable underlying disease.
Findings:
- Systemic treatment with high-dose methylprednisolone and azathioprine, combined with hydrocolloid dressings, promoted scar tissue healing.
- Maintenance therapy with low-dose aspirin (100 mg/day) was initiated.
Implications:
- This case demonstrates that anticardiolipin syndrome can present with purely cutaneous manifestations.
- Effective management involves immunosuppressive therapy and anticoagulation, potentially preventing relapse.