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Neonatal candidiasis associated with meningitis and endophthalmitis
1Department of Pediatrics, Chung Shan Medical and Dental College Hospital, Taichung, Taiwan, Republic of China.
Acta Paediatrica Japonica : Overseas Edition
|June 1, 1994
Summary
Systemic candidiasis in neonates is serious. Early diagnosis via cerebrospinal fluid (CSF) analysis and eye exams is crucial for infants with suspected Candida albicans infections.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Mycology
Background:
- Candida albicans poses a significant threat to neonates, particularly in intensive care settings.
- Risk factors include indwelling catheters, parenteral nutrition, and mechanical ventilation.
- Systemic candidiasis can lead to severe complications like meningitis and endophthalmitis.
Purpose of the Study:
- To investigate the clinical features and outcomes of systemic candidiasis in infants.
- To evaluate the effectiveness of antifungal treatment.
- To recommend diagnostic strategies for early detection.
Main Methods:
- Retrospective analysis of 11 infants with Candida albicans bloodstream infections.
- Review of clinical data, including risk factors and presenting symptoms.
- Assessment of treatment protocols and patient outcomes.
Main Results:
- Meningitis occurred in 54.5% of infants, and endophthalmitis in 45.5%.
- Common clinical signs included respiratory distress, poor activity, abdominal distension, and apnea.
- Three out of 11 infants (27.3%) died despite amphotericin B treatment.
Conclusions:
- Systemic candidiasis in neonates is associated with high rates of meningitis and endophthalmitis.
- Cerebrospinal fluid (CSF) analysis and indirect ophthalmoscopy are recommended for suspected cases.
- Prompt diagnosis and treatment are vital for improving outcomes in neonatal candidiasis.