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Related Experiment Videos

Validity testing of the EZ-SCREEN cannabinoid test

A J Jenkins1, L C Mills, W D Darwin

  • 1Addiction Research Center, NIDA, Baltimore, MD 21224.

Journal of Analytical Toxicology
|September 1, 1993
PubMed
Summary
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The EZ-SCREEN cannabinoid test accurately detects marijuana use, showing high sensitivity to THCCOOH. However, reader agreement varied, and delayed readings reduced accuracy in this drug testing validity study.

Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Clinical Chemistry

Background:

  • On-site drug testing offers rapid results but requires validation.
  • Limited data exists on the accuracy of rapid cannabinoid tests.

Purpose of the Study:

  • To assess the validity of the EZ-SCREEN cannabinoid test for detecting marijuana use.
  • To compare EZ-SCREEN results with Gas Chromatography/Mass Spectrometry (GC/MS).

Main Methods:

  • Three volunteers consumed varying amounts of marijuana.
  • Urine samples were tested using EZ-SCREEN and GC/MS for 11-nor-9-carboxy-delta 9-tetrahydrocannabinol (THCCOOH).
  • Results were analyzed blindly by three readers, with concordance assessed against GC/MS.

Main Results:

Related Experiment Videos

  • EZ-SCREEN demonstrated high sensitivity for THCCOOH at 5 ng/mL.
  • Low cross-reactivity was observed with delta 9-tetrahydrocannabinol (THC) and other cannabinoids.
  • No false positives occurred, but reader agreement was ~80%, with delayed readings showing lower accuracy.

Conclusions:

  • The EZ-SCREEN test is a sensitive method for detecting cannabinoids in urine.
  • Reader interpretation and timing of readings impact test accuracy.
  • Further validation is recommended for on-site cannabinoid testing.