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[Development and evaluation of an electrocatalytic glucose sensor for diabetes therapy]
W Preidel1, S Saeger, M J Stanzel
1Zentralabteilung Forschung und Entwicklung, Siemens AG, Erlangen.
Biomedizinische Technik. Biomedical Engineering
|November 1, 1993
Summary
A novel electrocatalytic glucose sensor enables continuous in vivo glucose monitoring. This implantable sensor demonstrated long-term stability, functioning for up to 71 days in sheep.
Area of Science:
- Biomedical Engineering
- Electrochemistry
- Implantable Sensors
Context:
- Continuous glucose monitoring is crucial for diabetes management.
- Existing methods often require frequent calibration or are invasive.
- Development of stable, long-term in vivo glucose sensors is needed.
Purpose:
- To develop and evaluate an electrocatalytic glucose sensor for continuous in vivo glucose measurement.
- To assess the long-term stability and performance of the sensor in an animal model.
- To investigate and mitigate cross-sensitivity to blood components and medicaments.
Summary:
- An electrocatalytic glucose sensor was developed for in vivo glucose level measurement via impedance changes.
- The sensor was implanted in sheep (carotid artery and vena cava) to evaluate long-term stability (up to 71 days for flow-through, 30 days for catheter).
- Cross-sensitivity was addressed through sensor calibration, maintaining functionality.
Impact:
- Provides a potential solution for long-term, continuous in vivo glucose monitoring.
- Demonstrates the feasibility of implantable electrochemical sensors for physiological measurements.
- Offers improved diabetes management through reliable, real-time glucose data.