[The mechanisms of the hepatotoxicity of complex platinum compounds]

Cisplatin and platin given in LD50 to mice caused significant changes in hepatic metabolism. There was enhanced lipid peroxidation with accumulation of malonic dialdehyde, dienic conjugates, Schiff bases, decreased antiradical activity and alterations in the fractional composition of phospholipids with higher concentrations of membranotoxic ingredients. There was also an increase in the serum activity of transaminases and alkaline phosphatase.