Indocyanine green video-angiographic findings in Harada's disease

Indocyanine green (ICG) video-angiography was performed in 8 cases of Harada's disease and the findings were compared with those of fluorescein angiography. ICG video-angiography was confirmed to be far superior to fluorescein angiography in evaluating the choroidal vasculature seen in Harada's disease. Before retinal detachment appeared, the early phase of ICG video-angiography revealed decreased numbers of large fluorescent choroidal vessels as well as patchy areas of hypofluorescence. When retinal detachment became prominent, the large fluorescent choroidal vessels seen on ICG video-angiography were significantly fewer in number and patchy areas of hypofluorescence could be seen in the early phase. In the late phase, pooling of dye leakage became prominent. When retinal detachment subsided, the number of fluorescent choroidal vessels had increased. These results suggest that the decreased number of large fluorescent choroidal vessels seen in the early phase of ICG video-angiography indicate circulatory disturbance of the choroidal vessels, the degree of which may correspond to the exudative retinal detachment characteristic of Harada's disease. Patchy areas of hypofluorescence indicated blockage due to multiple choroidal granulomas and Dalen-Fuchs nodules.