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Evaluation of delayed hypersensitivity: from PPD to poison ivy
1Division of Allergy/Immunology, Albert Einstein College of Medicine, Bronx, New York 10461.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|November 1, 1993
Summary
Delayed hypersensitivity (DTH) skin testing assesses cell mediated immunity (CMI) using recall antigens. Multitest CMI devices offer a standardized approach for anergy screening and allergy testing.
Area of Science:
- Immunology
- Dermatology
Background:
- Cell mediated immunity (CMI) involves lymphocytes, macrophages, and cytokines.
- Delayed hypersensitivity (DTH) skin testing is a key in vivo method to assess CMI.
- DTH testing has applications in anergy screening, infection detection, and contact allergen sensitivity.
Purpose of the Study:
- To review the applications and methodologies of DTH skin testing.
- To highlight the utility of standardized antigen devices like Multitest CMI.
- To discuss limitations and best practices for DTH testing.
Main Methods:
- Intradermal injection of recall antigens for anergy screening.
- Use of specific antigens for tuberculosis screening.
- Application of standardized allergen panels for contact allergy testing.
Main Results:
- Multitest CMI addresses challenges with antigen potency and availability.
- Tuberculosis screening remains a primary indication for infection testing via DTH.
- Accurate contact allergy testing necessitates adherence to approved allergen lists and techniques.
Conclusions:
- DTH skin testing is a valuable tool for evaluating CMI.
- Standardized testing devices improve reliability and accessibility.
- Proper technique and antigen selection are crucial for accurate DTH results.