Differential regulation of IGF-I leader exon transcription

We have shown that there is differential expression of the two IGF-I leader exons during physiological changes in GH and nutritional status in liver, with exon 2 being more responsive than exon 1. It may be that this exon is responsible for endocrine IGF-I synthesised in response to specific anabolic stimuli inducing subsequent whole body and skeletal muscle growth.