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Physiologic support of the septic patient
R H Demling1, C Lalonde, K Ikegami
1Longwood Area Trauma Center, Brigham and Women's Hospital, Boston, Massachusetts.
The Surgical Clinics of North America
|June 1, 1994
Abstract:
The patient's response to inflammation, referred to as sepsis, is a complex process involving the degree of the inflammatory insult and the host response. Ischemia, from blood flow abnormalities and direct cell injury from mediators, produces the physiologic response. The treatment is focused first on restoring and maintaining perfusion through maintenance of increased oxygen delivery. The second approach is first surgical then pharmacologic attenuation of the inflammation-induced injury.