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Safety profile of Colgate Platinum Professional Toothwhitening System
Compendium (Newtown, Pa.). Supplement
|January 1, 1994
Summary
Colgate Platinum, a professional tooth-whitening paste, was found safe in toxicity and irritation studies. This professional dental product containing urea peroxide demonstrated no adverse effects, mutagenicity, or oral tissue damage.
Area of Science:
- Dental hygiene
- Toxicology
- Oral health
Background:
- Professional tooth-whitening products require rigorous safety assessments.
- Urea peroxide is a common active ingredient in dental bleaching agents.
Purpose of the Study:
- To evaluate the safety of Colgate Platinum, a professional tooth-whitening paste.
- Assess acute oral toxicity, genotoxicity, and oral mucosa irritation potential.
Main Methods:
- Acute oral toxicity study in rats (single dose 5 g/kg).
- Genotoxicity assessment using Ames/Salmonella assay and in vivo bone marrow micronucleus test.
- 28-day repeated application oral mucosa irritation study in rats.
Main Results:
- No adverse effects observed after acute oral administration.
- Negative results in mutagenicity and primary DNA damage assays.
- No damage to oral tissues observed after repeated application.
Conclusions:
- Colgate Platinum demonstrates a favorable safety profile for its intended use.
- The product is not acutely toxic, genotoxic, or irritating to oral mucosa.
- Data supports the safe use of this professional tooth-whitening paste.