[The complex technology of producing rickettsial diagnostic immunoglobulin preparations and comparative...

The author elaborated a complex technology of production of a number of rickettsial diagnostic immunoglobulin preparations with a different action spectrum on the basis of a single initial raw material--horse immune serum. Horses immunized and reimmunized according to the original combined scheme served as producers of high-quality immune sera for multi-directed purposes. On the basis of such sera there were prepared dry fluorescent antibodies, immunoglobulin erythrocytic diagnostic agents, diagnostic sera for the complement fixation agglutination, indirect hemagglutination, and immunofluorescent microagglutination tests intended for detection of antigens of rickettsia of the typhus group and of the group of tick spotted fever, and also of specific immunoglobulins. Complex technology had anumber of technico-economic, and organizational advantages over the routine one.