[Angio-invasive disseminated aspergillosis: autopsy diagnosis in leukemic patients]

We report on two patients with acute lymphoblastic leukemia in induction chemotherapy, who developed a sepsis which led, in both cases, to death following the appearance of neurological symptoms suggesting CNS affectation. Autopsy revealed an angioinvasive disseminated aspergillosis affecting lungs, brain, myocardium, kidneys, thyroid glands in both cases, and endocardium, urinary bladder, lymph nodes, alimentary tract, nasal sinuses in one of the cases. Microbiology study of necropsic tissue showed Aspergillus flavusoryzae and likewise Candida albicans in one case. The latter finding suggest a combined fungal sepsis caused to candida and aspergillus.