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Updated: Aug 11, 2026

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
Published on: December 8, 2019
Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T
1Division of Experimental Oncology D, National Tumor Institute, Milan, Italy.
Abstract:
Oncogenic transformation is often accompanied by a significant overproduction of otherwise normal cellular proteins. Because of the low expression of such self components during thymic development, T cells specific for these antigens can escape deletion and progress to the periphery. In this viewpoint, Giorgio Parmiani discusses the concept that these T cells can be harnessed to provide an effective anti-tumor response.
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