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Published on: October 18, 2017
Invasive infection due to Apophysomyces elegans in immunocompetent hosts
W G Weinberg1, B H Wade, G Cierny
1Southeast Permanente Medical Group, Atlanta, Georgia.
Summary
A rare fungal infection caused by Apophysomyces elegans led to severe cellulitis and bone infection in a healthy man. Treatment involved antifungal medication and surgical removal of infected tissue.
Area of Science:
- Mycology
- Infectious Diseases
- Dermatology
Background:
- Zygomycoses are a group of fungal infections, often associated with underlying health conditions.
- Apophysomyces elegans is a rare fungal genus known to cause infections.
Observation:
- A previously healthy 59-year-old man presented with necrotizing cellulitis and osteomyelitis.
- The infection occurred at the site of a suspected insect bite or sting.
- Apophysomyces elegans was identified as the causative pathogen.
Findings:
- This case represents the seventh reported infection caused by Apiphenylomyces elegans.
- Six out of seven reported cases occurred in individuals without significant underlying diseases.
- Treatment required intravenous amphotericin B and en bloc resection for successful cure.
Implications:
- Apiphenylomyces elegans infections can occur in immunocompetent individuals, unlike many other zygomycoses.
- Early diagnosis and aggressive treatment, including surgical intervention, are crucial for managing these infections.
- Further research into the pathogenesis and epidemiology of Apiphenylomyces elegans is warranted.
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