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Central serous chorioretinopathy in endogenous hypercortisolism
E A Bouzas1, M H Scott, G Mastorakos
1Ophthalmic Genetics and Clinical Services Branch, National Eye Institute, National Institutes of Health, Bethesda, Md.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|September 1, 1993
Summary
Central serous chorioretinopathy is an uncommon finding in patients with Cushing's syndrome. This study suggests a potential role for glucocorticoids in the development of central serous chorioretinopathy.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Endogenous hypercortisolism, also known as Cushing's syndrome, is a condition characterized by prolonged exposure to high cortisol levels.
- Central serous chorioretinopathy (CSC) is a condition affecting the retina, leading to visual disturbances.
Observation:
- This study surveyed 60 patients with confirmed endogenous Cushing's syndrome undergoing ophthalmologic evaluation.
- The research was conducted at an eye clinic within a research center.
Findings:
- Three patients (5%) with Cushing's syndrome experienced episodes of central serous chorioretinopathy.
- All documented CSC episodes occurred during periods of active hypercortisolism.
Implications:
- Central serous chorioretinopathy appears to be an infrequent manifestation of endogenous Cushing's syndrome.
- The findings suggest that elevated glucocorticoid levels may contribute to the pathogenesis of central serous chorioretinopathy.