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Reference values and participant means as targets in proficiency testing

D W Tholen1

  • 1College of American Pathologists, Traverse City, MI.

Archives of Pathology & Laboratory Medicine
|September 1, 1993
PubMed
Summary

Proficiency testing (PT) is crucial for laboratory licensing. Participant-derived targets are highly accurate and reliable for determining correct PT results, ensuring quality in laboratory testing.

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Area of Science:

  • Clinical Laboratory Science
  • Analytical Chemistry
  • Quality Assurance in Healthcare

Background:

  • Regulatory agencies increasingly rely on proficiency testing (PT) for laboratory licensing.
  • Accurate target value determination in PT is critical for laboratory accreditation.
  • Three methods for establishing PT target values are proposed: participant-derived, reference laboratory, and definitive values.

Purpose of the Study:

  • To review the College of American Pathologists' (CAP) historical experiences with different PT target value determination methods.
  • To describe the evolution of CAP's current PT protocol.
  • To outline methods used by CAP to monitor the accuracy of PT target values.

Main Methods:

  • Review of historical data and protocols from the College of American Pathologists (CAP) Surveys programs.
  • Analysis of participant-derived consensus results for accuracy and reliability.
  • Utilization of definitive methods and certified reference materials from the National Institute of Standards and Technology (NIST) for target value validation.

Main Results:

  • Participant-derived "consensus" results have demonstrated high accuracy and reliability in PT.
  • The CAP has employed a range of target value determination techniques throughout its history.
  • Ongoing monitoring using definitive methods and certified reference materials validates CAP's PT targets.

Conclusions:

  • Participant-derived target values are a valid and reliable method for proficiency testing.
  • The CAP's evolving approach to target value determination ensures the accuracy of PT results.
  • Continuous monitoring strengthens the integrity of PT programs essential for laboratory quality.

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