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[Oral emulsions: preparation and bioavailability]

N S Santos Magalhaes1, S Benita, M Seiller

  • 1Universidade Federal de Pernambuco, Departamento de Farmacia, Recife, PE Brasil.

Journal De Pharmacie De Belgique
|May 1, 1993
PubMed
Summary

Oral lipid/hemoglobin (L/H) emulsions are rare but effective pharmaceutical dosage forms. These systems offer easy administration, protect lipophilic drugs, and control drug release for improved bioavailability.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Formulation Development

Context:

  • Oral lipid/hemoglobin (L/H) emulsions represent an uncommon yet valuable pharmaceutical formulation.
  • These systems are recognized for their ease of administration and protective capabilities for sensitive lipophilic active substances.
  • They offer a unique approach to modulating drug release kinetics.

Purpose:

  • To review the key components of oral L/H emulsions, including oils, surfactants, and active pharmaceutical ingredients.
  • To elucidate the mechanisms of bioavailability associated with these emulsions and identify key influencing factors.
  • To discuss in vitro evaluation methods for assessing drug release from L/H emulsion formulations.

Summary:

  • This review covers the essential constituents of oral L/H emulsions, such as oils, surfactants, and active compounds.
  • It details the bioavailability mechanisms and critical factors affecting drug absorption from these systems.
  • The discussion includes various in vitro methods for analyzing drug release profiles.

Impact:

  • Provides a comprehensive overview of oral L/H emulsions for researchers and formulators.
  • Highlights the potential of L/H emulsions in enhancing the delivery of lipophilic drugs.
  • Offers insights into the evaluation of drug release, crucial for formulation optimization and clinical application.

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