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Related Experiment Videos

Ipsilateral hypohidrosis in brain stem infarction

J T Korpelainen1, K A Sotaniemi, V V Myllylä

  • 1Department of Neurology, University of Oulu, Finland.

Stroke
|January 1, 1993
PubMed
Summary

Brain stem stroke causes long-lasting ipsilateral sweating dysfunction (hypohidrosis). This autonomic failure is common, affecting most patients on the side of the infarction, and persists for at least six months.

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Area of Science:

  • Neurology
  • Autonomic Neuroscience
  • Clinical Medicine

Background:

  • The brain stem is a critical autonomic processing center.
  • Clinical manifestations of autonomic failure in brain stem stroke are under-recognized.
  • Sweating dysfunction is a key indicator of autonomic function.

Purpose of the Study:

  • To evaluate the prevalence of sweating dysfunction in brain stem infarctions.
  • To characterize the nature and duration of autonomic failure related to sweating.
  • To assess the prognostic significance of sweating abnormalities post-stroke.

Main Methods:

  • Prospective study design.
  • Quantitative evaporimetry used to measure sweating.
  • Inclusion of 18 healthy controls and 18 patients with acute ischemic brain stem stroke.

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  • Assessment at acute phase, 1 month, and 6 months post-infarction.

    • Main Results:

    • Significantly reduced sweating on the ipsilateral side of the infarction compared to the contralateral side.
    • Ipsilateral hypohidrosis observed in 83% acutely, 100% at 1 month, and 76% at 6 months.
    • No significant difference in sweating response between medullary and pontine infarcts.

    Conclusions:

    • Long-lasting, whole-body ipsilateral hypohidrosis is a significant feature of autonomic failure in brain stem infarction.
    • This previously undescribed phenomenon highlights the impact of brain stem stroke on autonomic regulation.
    • Sweating dysfunction is a crucial, persistent clinical manifestation following brain stem infarction.