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Disseminated intravascular coagulation

J A Gilbert1, R P Scalzi

  • 1Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.

Emergency Medicine Clinics of North America
|May 1, 1993
PubMed
Summary
This summary is machine-generated.

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Disseminated Intravascular Coagulation (DIC) is a dangerous bleeding and clotting disorder with many causes. Early recognition and treating the underlying condition are key for emergency physicians, as mortality remains high despite treatments.

Area of Science:

  • Hematology
  • Critical Care Medicine
  • Emergency Medicine

Background:

  • Disseminated Intravascular Coagulation (DIC) is a complex and life-threatening disorder characterized by systemic activation of coagulation, leading to abnormal clot formation and consumption of clotting factors and platelets.
  • It presents with a wide spectrum of clinical manifestations and is associated with numerous underlying conditions, making diagnosis and management challenging.

Purpose of the Study:

  • To review the pathophysiology, causes, diagnostic criteria, and therapeutic strategies for Disseminated Intravascular Coagulation (DIC).
  • To emphasize the critical role of emergency physicians in the early recognition and management of at-risk patients.

Main Methods:

  • This review synthesizes current literature on DIC, focusing on clinical and laboratory diagnostic approaches.

Related Experiment Videos

  • It discusses various therapeutic options, highlighting controversies and the importance of individualized treatment based on clinical presentation.

    • Main Results:

    • DIC involves a consumptive process leading to multiple coagulation, platelet, and fibrinolytic abnormalities.
    • Despite aggressive management and ongoing research, mortality rates associated with DIC remain high.
    • Diagnosis requires a combination of clinical assessment and laboratory findings.

    Conclusions:

    • Effective management of DIC hinges on prompt recognition of at-risk patients and addressing the primary underlying disorder.
    • Therapeutic interventions for DIC are often controversial and should be tailored to specific clinical scenarios.
    • The emergency physician plays a pivotal role in the initial management and disposition of patients with DIC.