Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats
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Updated: Aug 4, 2026
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
J K Kirejczyk1, L Chyczewski, W Debek
1Department of Pediatric Surgery, Medical Academy of Bialystok.
Abstract:
Degree of renal damage in experimental untreated and treated hemorrhagic shock was estimated in light microscopy. Histological preparations were scored with a semiquantitative scale concerning the changes which are typical for the acute renal failure. It was found that an early treatment with the PAF-receptor antagonist (ginkgolide BN 52021) considerably reduced morphological changes observed in rat kidney in hemorrhagic shock, comparing with untreated shock and in shock treated with a polyelectrolyte solution.
Insights
Early treatment with ginkgolide BN 52021, a platelet-activating factor receptor antagonist, significantly reduced kidney damage in rats experiencing hemorrhagic shock. This protective effect was observed compared to untreated shock or shock treated with a polyelectrolyte solution.
Area of Science:
- Nephrology
- Pathology
- Pharmacology
Background:
- Hemorrhagic shock can lead to acute kidney injury.
- Platelet-activating factor (PAF) plays a role in inflammatory responses during shock.
- Novel therapeutic strategies are needed to mitigate renal damage in shock.
Purpose of the Study:
- To evaluate the protective effect of a PAF-receptor antagonist, ginkgolide BN 52021, on renal damage in experimental hemorrhagic shock.
- To compare the efficacy of ginkgolide BN 52021 with standard treatment in preventing kidney injury.
Main Methods:
- Experimental hemorrhagic shock was induced in rats.
- Renal damage was assessed using light microscopy and a semiquantitative scoring scale for acute renal failure.
- Animals were divided into groups: untreated shock, shock treated with ginkgolide BN 52021, and shock treated with a polyelectrolyte solution.
Main Results:
- Untreated hemorrhagic shock resulted in significant morphological changes indicative of acute renal failure.
- Early treatment with ginkgolide BN 52021 markedly reduced these pathological changes in the rat kidney.
- The protective effect of ginkgolide BN 52021 was superior to that of the polyelectrolyte solution.
Conclusions:
- Ginkgolide BN 52021 demonstrates significant renoprotective effects in experimental hemorrhagic shock.
- Targeting the PAF receptor may be a promising therapeutic approach for preventing acute kidney injury during shock.
- Further research into PAF antagonists for shock management is warranted.
