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Myelopeptides: new immunoregulatory peptides
1Academy of Sciences of Russia, Moscow.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|July 1, 1995
Summary
Myelopeptides (MPs) are bioregulatory peptides from bone marrow with diverse functions. A drug derived from MPs, Myelopidum, effectively treats immunodeficiency, prevents surgical complications, and aids chronic pulmonary disease patients.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Background:
- Bone marrow cells produce bioregulatory peptides known as myelopeptides (MPs).
- Myelopeptides exhibit immunoregulatory, differentiating, and opiate-like activities.
- Physico-chemical properties of MPs have been characterized.
Purpose of the Study:
- To investigate the functional activities of myelopeptides.
- To highlight the therapeutic applications of Myelopidum, an MP-based drug.
- To establish the primary structure and function of specific MPs like MP-1 and MP-2.
Main Methods:
- Isolation and purification of myelopeptides.
- Investigation of physico-chemical properties.
- Clinical and veterinary application studies of Myelopidum.
- Determination of primary structures for selected MPs.
Main Results:
- Myelopidum effectively treats immunodeficiency-related diseases.
- Post-surgical administration of Myelopidum reduces complications by 50-70%, including pneumonia.
- Myelopidum normalizes T-helper, T-suppressor, and B-lymphocyte balance in chronic pulmonary disease patients, prolonging remission.
- Myelopidum is used in veterinary medicine for pneumonia and enteritis prophylaxis and treatment.
Conclusions:
- Myelopidum is a clinically effective immunocorrective drug derived from myelopeptides.
- Myelopidum demonstrates significant benefits in surgical recovery and chronic pulmonary disease management.
- Further investigation into the functional activities of specific myelopeptides (MP-1, MP-2) is ongoing.