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Instrumentation of an automatic capsule-filling machine
Journal of Pharmaceutical Sciences
|April 1, 1977
Summary
Strain gauges were adapted to monitor forces during capsule filling, revealing distinct precompression and compression stages. This method offers a minimally invasive way to analyze powder compaction during pharmaceutical manufacturing.
Area of Science:
- Pharmaceutical Engineering
- Mechanical Engineering
- Materials Science
Background:
- Tablet press instrumentation techniques were adapted for capsule-filling machines.
- Monitoring compression and ejection forces is crucial for optimizing capsule fill quality.
Purpose of the Study:
- To instrument an automatic capsule-filling machine to measure compression and ejection forces.
- To analyze the stages of powder slug formation during capsule filling.
Main Methods:
- Strain gauges were bonded to the compression piston of the dosing unit, forming a Wheatstone bridge.
- The instrumented piston was calibrated, and a mercury contact swivel was used for rotation.
- A solenoid switching system controlled gelatin shell feeding for the instrumented piston.
Main Results:
- Oscilloscope tracings identified two stages: precompression and actual piston compression.
- Maximum slug compression force typically dropped rapidly upon piston retraction, with occasional retention force noted.
- Lubricated batches showed lower ejection forces (< 1 kg).
Conclusions:
- The developed instrumentation system allows for effective monitoring of forces during capsule filling.
- The study provides insights into powder behavior and slug formation.
- This technique requires minimal permanent modification to the capsule-filling machine.