An interactive computer program for determining areas bounded by drug concentration curves using lagrange...

The LAGRAN method of Rocci and Jusko for determining the area of plasma concentration curves has been implemented in a user-friendly form. Drug concentration versus time data may be entered using the keyboard or imported in the form of simple text files from spreadsheets or other software. The MSDOS program allows prompt graphic observation of the data. The effect of selecting different fitting modes for each segment of the curve may be viewed interactively using this graphic display. Pharmacokinetic parameters that are provided by the program include mean residence time, variance of the residence time, plasma clearance, and steady-state volume of distribution.