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Skin side-effects of amiodarone therapy
Sbornik Vedeckych Praci Lekarske Fakulty Karlovy University V Hradci Kralove
|January 1, 1993
Summary
Amiodarone, an antiarrhythmic drug, can cause photosensitivity and greyish-blue skin pigmentation. A phototest study found these side effects in patients, confirmed by histological examination.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Medicine
Background:
- Amiodarone is an antiarrhythmic medication.
- It is known to cause various side effects.
- Skin reactions like photosensitivity and hyperpigmentation are reported.
Purpose of the Study:
- To investigate the incidence of photosensitivity and skin hyperpigmentation in patients treated with amiodarone.
- To evaluate the clinical and histological features of these amiodarone-induced skin reactions.
Main Methods:
- A phototest using a xenon lamp was conducted on 64 patients receiving amiodarone and 32 controls.
- Histological examination, including electron microscopy, was performed on hyperpigmented skin samples.
Main Results:
- Photosensitivity was observed in 9.4% of amiodarone-treated patients.
- Greyish-blue hyperpigmentations were noted on the face and hands of 9.4% of patients.
- Histological analysis confirmed the nature of these pigmentations.
Conclusions:
- Amiodarone can induce photosensitivity and characteristic skin hyperpigmentations.
- These side effects warrant clinical attention in patients undergoing amiodarone therapy.
- Further histological investigation aids in understanding these dermatological manifestations.