Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain POU-er

Z D Sharp1, W W Morgan

  • 1University of Texas Institute of Biotechnology, San Antonio, USA. sharp@uthscsa.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Coordinated development of the brain and its organs is complex. POU-domain proteins are critical for the development of the hypothalamo-pituitary axis, integrating brain and endocrine functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apollo Next Generation Sample Analysis (ANGSA): an Apollo Participating Scientist Program to Prepare the Lunar Sample Community for Artemis.

Space science reviews·2024
Same author

Spatiotemporal control of estrogen-responsive transcription in ERα-positive breast cancer cells.

Oncogene·2015
Same author

Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice.

Frontiers in molecular neuroscience·2014
Same author

Letters. Waste incineration.

Environmental science & technology·2012
Same author

Carcass merit between and among family groups of Bos indicus crossbred steers and heifers.

Meat science·2011
Same author

Interrelationships of breed type, USDA quality grade, cooking method, and degree of doneness on consumer evaluations of beef in Dallas and San Antonio, Texas, USA.

Meat science·2011
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Endocrinology

Background:

  • Coordinated cell type appearance and spatial organization are crucial for vertebrate brain development.
  • The interplay between the developing brain and target organs presents significant biological complexity.
  • The hypothalamo-pituitary axis exemplifies the intricate development and integration of neuroendocrine systems.

Purpose of the Study:

  • To investigate the integrative mechanisms governing the development of the hypothalamo-pituitary axis.
  • To understand the role of specific molecular factors in coordinating hypothalamic and pituitary ontogeny.

Main Methods:

  • Utilized studies on the developing hypothalamo-pituitary axis.
  • Focused on the function of POU-domain proteins in developmental coordination.

Related Experiment Videos

Main Results:

  • Identified POU-domain proteins as key regulators in the coordinated development of the hypothalamus and pituitary.
  • Highlighted the critical role of these factors in the ontogeny of the neuroendocrine axis.

Conclusions:

  • POU-domain proteins are essential for synchronizing the development of the hypothalamus and pituitary gland.
  • Understanding these mechanisms provides insights into broader principles of developmental coordination in neuroendocrine systems.