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Nitric oxide-releasing polymers containing the [N(O)NO]- group
D J Smith1, D Chakravarthy, S Pulfer
1Department of Chemistry, University of Akron, Akron, Ohio 44325, USA.
Journal of Medicinal Chemistry
|March 1, 1996
Summary
Researchers developed polymers releasing nitric oxide (NO) for targeted drug delivery. These materials show sustained NO release and potential in biomedical applications, including antiplatelet therapy and inhibiting cell proliferation.
Area of Science:
- Materials Science
- Biomedical Engineering
- Pharmacology
Background:
- The functional group X[N(O)NO]- exhibits pharmacological activity linked to nitric oxide (NO) release.
- Controlling the rate and location of NO release is crucial for therapeutic applications.
Purpose of the Study:
- To incorporate the [N(O)NO]- functional group into polymeric matrices for controlled NO delivery.
- To investigate the potential of these NO-releasing polymers in biomedical applications.
Main Methods:
- Synthesized polymers with the [N(O)NO]- group integrated into the polymer backbone, as pendant groups, or noncovalently distributed.
- Characterized NO release kinetics using chemiluminescence.
- Evaluated antiplatelet activity and effects on smooth muscle cell proliferation in vitro and in vivo.
Main Results:
- Polymers demonstrated sustained NO release for up to 5 weeks.
- A poly-(ethylenimine) prototype inhibited rat aorta smooth muscle cell proliferation.
- Coating vascular grafts with the polymer showed potent antiplatelet activity in baboons.
Conclusions:
- Polymers containing the [N(O)NO]- functional group can serve as localized sources of nitric oxide.
- These materials offer a promising platform for localized NO delivery in various biomedical applications.