[Antibiotic sensitivity of anaerobic bacteria isolated during one year (1993)]

The aim of this study was to determine the antimicrobian susceptibility of the anaerobe bacteria isolated from clinical samples in the authors' department in 1993.

The minimum inhibitory concentrations of 10 antimicrobians were determined in microgram/ml for 129 anaerobe bacterias by the microdilution in broth method recommended by the NCCLS.

All The strains were sensitive to chloramphenicol. Metronidazole inhibited all the isolates except A. meyeri and 50% of other non spored gram-positive bacilli. Imipenen and piperacillin-tazobactam were the most active beta lactamics, with only 1 B. fragilis being resistant to both. Clavulanic amoxycillin presented good activity with only 5% from the B. fragilis group, 1 F. mortiferum and 2 P. anaerobius being resistant. In the B. fragilis group 10% were resistant to cefoxitin and 15% to piperacillin. The remaining isolates were sensitive to both antimicrobians. Resistance to clindamycin in the B. fragilis group was 16.7%. There were also strains resistant to Peptostreptococcus, Prevotella and aerotolerant non spored gram-positive bacilli. Penicillin and amoxycillin were the least active antimicrobians.

Chloramphenicol, metronidazole, imipenem, piperacillin-tazobactam and clavulanic amoxycillin were very effective and showed a wide spectrum of activity versus the strains studied. Cefoxitin, piperacillin and clindamycin maintain good antianaerobe activity.