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Sib-based detection of QTLs
B K Suarez1, C L Hampe, D O'Rourke
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Genetic Epidemiology
|January 1, 1995
Abstract:
Association and transmission/nontransmission analyses were used in a split sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on various subsets of the data identified an additional four regions that yielded signals of disease predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I errors. A new simulation indicates that a multiplex sampling strategy would substantially improve QTL detection for this oligogenic transmission model.