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Synthesis and structure-activity relationship of trimebutine derivatives
1Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd., Osaka, Japan.
Chemical & Pharmaceutical Bulletin
|June 1, 1996
Abstract:
Trimebutine derivatives were synthesized by utilizing alkylation or acylation of isonitriles and nitrile as a key step. The colonic contractile effects of these compounds were examined, and T-1815 was found to have strong colonic propulsive activity.
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