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Severe infection due to Actinomyces bernardiae: case report
M Ieven1, J Verhoeven, P Gentens
1Department of Microbiology, University Hospital, Antwerpen, Belgium.
Summary
This study details a severe urinary tract infection caused by Actinomyces bernardiae in a patient with chronic bladder dysfunction. The infection led to significant complications including kidney damage and sepsis.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Urology
Background:
- Actinomyces species are known human pathogens, but Actinomyces bernardiae (formerly CDC fermentative coryneform group 2) is rarely reported as a cause of infection.
- Urinary tract infections (UTIs) can lead to severe complications, especially in patients with underlying urinary tract abnormalities.
Observation:
- A patient with long-standing bladder dysfunction presented with a serious UTI.
- The patient developed hydroureteronephrosis, renal lithiasis (kidney stones), perirenal abscesses, and septicemia.
Findings:
- Actinomyces bernardiae was identified as the causative agent of the severe UTI and subsequent complications.
- Genetic and phenotypic analysis confirmed A. bernardiae is distinct from Actinomyces pyogenes and other CDC coryneform groups.
Implications:
- This case highlights A. bernardiae as a potential pathogen in complex UTIs, particularly in immunocompromised or functionally impaired patients.
- Accurate identification and differentiation of Actinomyces species are crucial for appropriate treatment and understanding pathogenesis.
- Further research is needed to elucidate the prevalence and virulence factors of A. bernardiae in clinical settings.