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Related Experiment Videos

Immunology: resistance to paratuberculosis

R J Chiodini1

  • 1International Association for Paratuberculosis, Inc. Rehoboth, Massachusetts, USA.

The Veterinary Clinics of North America. Food Animal Practice
|July 1, 1996
PubMed
Summary

Mycobacterium paratuberculosis causes disease through complex immune cell interactions. Resistance requires a strong cellular immune response to infection and reinfection, otherwise immune reactions cause disease manifestations.

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Area of Science:

  • Immunology
  • Veterinary Medicine
  • Microbiology

Background:

  • Johne's disease, caused by Mycobacterium paratuberculosis, affects ruminants.
  • The disease involves intricate interactions between lymphoid and phagocytic cells in immune responses.
  • Both peripheral and mucosal immunity play roles in the disease pathogenesis.

Purpose of the Study:

  • To elucidate the immunologic mechanisms underlying Mycobacterium paratuberculosis infection.
  • To understand the factors contributing to disease resistance versus susceptibility.
  • To explore the role of immune reactions in disease manifestation.

Main Methods:

  • Analysis of lymphoid and phagocytic cell interactions.
  • Evaluation of cellular immune responses to primary and secondary infections.
  • Characterization of the immunologic spectrum in infected animals.

Main Results:

  • Disease pathogenesis is linked to complex immune cell interplay.
  • Effective cellular immunity is crucial for resistance to Mycobacterium paratuberculosis.
  • Failure to mount an adequate immune response leads to immunopathology.

Conclusions:

  • Mycobacterium paratuberculosis infection outcome depends on the host's immune response.
  • The immune system's reaction, not just the pathogen, drives disease symptoms.
  • Understanding these immune dynamics is key for managing Johne's disease.

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