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Stents wrapped in autologous vein: an experimental study
C Stefanadis1, K Toutouzas, C Vlachopoulos
1Department of Cardiology, Hippokration Hospital, University of Athens, Greece.
Journal of the American College of Cardiology
|October 1, 1996
Summary
This study developed a novel autologous vein graft-coated stent, finding it non-thrombogenic with minimal hyperplasia in pigs. Further human trials are needed to assess this innovative stent technology.
Area of Science:
- Vascular surgery
- Biomaterials science
- Interventional cardiology
Background:
- Stenting limitations necessitate innovative solutions.
- Autologous tissue-coated stents remain experimentally underexplored.
- This study introduces a novel autologous vein graft-coated stent.
Purpose of the Study:
- To develop and evaluate a novel stent coated with autologous vein graft.
- To assess the feasibility, safety, and preliminary efficacy of this coated stent in a porcine model.
- To compare the outcomes of coated stents versus conventional stents.
Main Methods:
- Developed a Palmaz stent coated internally and externally with autologous vein graft.
- Implanted 27 coated stents in pig iliac arteries, with 15 non-coated stents as controls.
- Conducted angiographic follow-up for up to 6 months and performed histomorphometric analysis.
Main Results:
- Coated stent preparation and implantation were feasible and uncomplicated.
- Absence of thrombosis in coated stents, contrasted with two subacute thrombosis cases in controls.
- Greater intimal layer thickness and thinner arterial media observed in coated stents compared to controls.
Conclusions:
- The autologous vein graft-coated stent demonstrated non-thrombogenic properties.
- Minimal hyperplasia was observed, suggesting good biocompatibility.
- Further investigation in human subjects is warranted to confirm clinical efficacy.