Effects of postoperative intraperitoneal chemotherapy on peritoneal wound healing and adhesion formation

The relatively low incidence of abdominal adhesions following the use of postoperative intraperitoneal chemotherapy should not restrict the indications of these treatments. However, some drugs appear to have a documented sclerotic effect on the peritoneum causing intraabdominal adhesions. Studies should be conducted on drug dosage, drug scheduling, and the use of additional treatments such as nonsteroidal antiinflammatory or fibrinolytic drugs that could reduce adhesion formation after intraperitoneal infusion of vesicant drugs.