[Endobronchial brachytherapy with high dose rate 192Ir afterloading technique using a new applicator]

Area of Science:

• Oncology
• Radiation Oncology
• Medical Physics

Background:

• High dose rate endobronchial brachytherapy is used for lung cancer.
• Current methods risk overdose due to source adherence to the bronchial wall.

Purpose of the Study:

• To introduce a novel applicator for Ir-192 high dose rate brachytherapy.
• To establish reference points based on bronchial diameter for optimal dose distribution.

Main Methods:

• A new applicator was designed to center the Ir-192 source within the bronchial lumen.
• Reference dose points were set at 3, 5, 7, and 10 mm from the source, varying with bronchial diameter.
• Treatment involved external beam radiotherapy and endobronchial brachytherapy (curative or palliative intent).

Main Results:

• The new applicator was successfully used in 13 out of 19 treated patients.
• No significant side effects were observed during the follow-up period.
• The applicator facilitated precise source positioning, mitigating overdose risks.

Conclusions:

• The newly designed applicator enhances safety and efficacy in endobronchial brachytherapy for lung cancer.
• Setting reference points according to bronchial diameter is crucial for both curative and palliative treatments.