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Tinea inguinalis treated with miconazole cream: a double-blind study
Israel Journal of Medical Sciences
|June 1, 1977
Summary
2% miconazole cream effectively treated tinea inguinalis caused by Trichophyton rubrum in men. Patients experienced reduced itching and improved cure rates after 14 and 28 days of treatment.
Area of Science:
- Dermatology
- Mycology
- Clinical Pharmacology
Background:
- Tinea inguinalis is a common fungal infection affecting the groin area.
- Effective topical treatments are crucial for managing this condition.
- Dermatophytes, particularly Trichophyton rubrum, are frequent causative agents.
Purpose of the Study:
- To evaluate the efficacy and safety of 2% miconazole cream versus its vehicle in treating tinea inguinalis.
- To assess clinical and mycological outcomes in patients with confirmed causative agents.
Main Methods:
- A double-blind, placebo-controlled study was conducted.
- Eighty-four adult males diagnosed with tinea inguinalis participated.
- Treatment involved application of 2% miconazole cream or its vehicle for a specified duration.
Main Results:
- Miconazole cream showed significant improvement in relieving itching compared to the vehicle.
- Higher clinical and mycological cure rates were observed with miconazole treatment at 14 and 28 days.
- These positive outcomes were specifically noted in patients infected with Trichophyton rubrum.
Conclusions:
- 2% miconazole cream is an effective treatment for tinea inguinalis caused by Trichophyton rubrum.
- The study highlights the benefit of miconazole in reducing symptoms and achieving fungal clearance.
- Further investigation is needed for efficacy against other dermatophytes or Candida species.