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Irradiated uveal melanomas: cytopathologic correlation with prognosis
D H Char1, S M Kroll, T Miller
1Department of Ophthalmology, University of California, San Francisco, USA.
American Journal of Ophthalmology
|October 1, 1996
Summary
Cytopathologic data from fine-needle aspiration biopsies (FNABs) improve prognostic accuracy for patients with irradiated uveal melanoma. This analysis identified epithelioid cell percentage and ciliary body involvement as key indicators of melanoma-related mortality.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Uveal melanoma is the most common primary intraocular malignancy.
- Accurate prognostication is crucial for guiding treatment and predicting outcomes.
- Cytopathologic features may offer additional prognostic value beyond standard variables.
Purpose of the Study:
- To evaluate the added prognostic information from cytopathologic data in patients with uveal melanoma undergoing irradiation.
- To determine if fine-needle aspiration biopsy (FNAB) findings correlate with survival and local tumor recurrence.
Main Methods:
- Fine-needle aspiration biopsies (FNABs) were performed on 116 patients with uveal melanoma.
- Cytopathologic data, including cell type and ciliary body involvement, were reviewed in a masked manner.
- Statistical analysis using Kaplan-Meier and Cox models correlated cytopathologic variables with survival and recurrence.
Main Results:
- Cytopathologic assessment significantly enhanced prognostic accuracy for irradiated uveal melanoma.
- The percentage of epithelioid cells on FNAB was strongly correlated with melanoma-related mortality.
- Ciliary body involvement also demonstrated a significant correlation with adverse outcomes.
Conclusions:
- Fine-needle aspiration biopsy (FNAB) data provide valuable prognostic information for uveal melanoma patients receiving irradiation.
- Incorporating cytopathologic findings can improve risk stratification and patient management.