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[Retrospective and comparative study of pneumococcal bacteremia in patients with chronic hepatopathy]

J M Ramos Rincón1, M Cuenca Estrella, M L Fernández Guerrero

  • 1Servicio de Microbiología, Fundación Jiménez Díaz, Universidad Autónoma, Madrid.

Anales De Medicina Interna (Madrid, Spain : 1984)
|July 1, 1996
PubMed
Abstract

Insights

Patients with chronic liver disease are at higher risk for severe Streptococcus pneumoniae infections, including bacteremia. While outcomes are similar to those without liver disease, risk factors like alcoholism and elevated aminotransferases are significant.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Critical Care Medicine

Background:

  • Chronic hepatopathy increases susceptibility to severe infections, particularly Streptococcus pneumoniae bacteremia.
  • Patients with chronic liver disease face a higher risk of invasive pneumococcal disease.

Purpose of the Study:

  • To review the clinical characteristics and outcomes of patients with chronic hepatopathy and pneumococcal bacteremia.
  • To compare the clinical presentation and prognosis of pneumococcal bacteremia in patients with and without chronic liver disease.

Main Methods:

  • Retrospective review of 34 patients with chronic hepatopathy and pneumococcal bacteremia (HIV-negative).
  • Comparison of these patients with a control group of 140 HIV-negative patients with pneumococcal bacteremia.
  • Analysis of clinical characteristics, risk factors, and mortality rates.

Main Results:

  • Alcoholism and elevated aminotransferases were independent risk factors for pneumococcal bacteremia in chronic hepatopathy patients.
  • Pneumococcal bacteremia was frequently associated with pneumonia and peritonitis in this cohort.
  • While overall mortality was higher in patients with chronic hepatopathy (38% vs. 25%), the difference was not statistically significant. Septic shock indicated a poor prognosis (83% mortality).

Conclusions:

  • Pneumococcal bacteremia in patients with chronic hepatopathy carries a high mortality risk.
  • Despite the increased risk, the clinical outcomes for pneumococcal bacteremia in chronic hepatopathy patients are comparable to those without the condition.
  • Identifying risk factors such as alcoholism and managing complications like septic shock are crucial for improving patient outcomes.

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