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[Rifabutin-induced hypopyon iritis in HIV infection]
P R Diemer1, E W Zeh, E G Weidle
1Augenklinik des Katharinenhospitals Stuttgart.
Klinische Monatsblatter Fur Augenheilkunde
|July 1, 1996
Summary
Rifabutin, used for Mycobacterium avium infection in AIDS patients, can cause anterior uveitis. Discontinuing the drug and using anti-inflammatory eye drops resolved the condition in a case study.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Pharmacology
Background:
- Rifabutin is a semisynthetic rifamycin used for Mycobacterium avium intracellulare (MAI) infections in patients with Acquired Immunodeficiency Syndrome (AIDS).
- Anterior uveitis has been reported as a dose-dependent side effect of rifabutin, potentially exacerbated by co-administration with clarithromycin and/or fluconazole.
- The drug received approval in Germany in 1995.