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An unusual case of elastofibroma oculi
J K Hsu1, H D Cavanagh, W R Green
1Department of Ophthalmology, University of Texas Southewestern Medical Center at Dallas 75235-9057, USA.
Cornea
|January 1, 1997
Summary
This study describes a rare ocular lesion resembling elastofibroma in a competitive swimmer, likely caused by environmental exposures. The findings suggest a link between UV radiation, chlorine, and chronic inflammation in developing such growths.
Area of Science:
- Ophthalmology
- Dermatopathology
- Connective Tissue Biology
Background:
- Ocular surface lesions can be influenced by environmental factors and chronic inflammation.
- Elastofibromas are typically found in the subcapsular region, with rare occurrences in ocular tissues.
- Understanding the pathogenesis of fibrovascular growths on the cornea is crucial for diagnosis and management.
Observation:
- A 22-year-old competitive swimmer presented with bilateral, nasal, fluffy white corneal growths.
- Histopathological examination revealed a fibrovascular pannus with abundant immature elastic fibers and elastotic degeneration.
- The lesion's composition suggests a process involving both excessive elastic fiber production and degeneration.
Findings:
- The ocular lesion shares features with subcutaneous elastofibromas, indicating a potential shared pathway.
- Immature elastic fibers and elastotic changes were prominent, differing from mature elastic tissue.
- The presence of fibrocytes, inflammatory cells, and mast cells points to an inflammatory and reparative process.
Implications:
- This case expands the known spectrum of ocular fibrovascular lesions.
- Environmental factors like UV, wind, and chlorine exposure may play a significant role in the development of these lesions.
- Further research is needed to elucidate the precise mechanisms of elastic tissue alteration in ocular growths and their relationship to conditions like pingueculae and pterygia.