Related Experiment Videos
[Liver transplantation--present status]
1Department of Transplantation and Immunology, Kyoto University, Japan.
Nihon Geka Gakkai Zasshi
|November 1, 1996
Summary
Living related liver transplantation (LPLT) addresses donor shortages, offering a viable option for end-stage liver disease patients. Addressing infection risks and ABO incompatibility are key to improving LPLT outcomes and expanding its use.
Area of Science:
- Hepatology
- Transplantation Surgery
- Immunology
Context:
- Donor shortage for cadaveric liver transplantation (CLT) necessitates alternative strategies.
- Living related liver transplantation (LPLT) and split/reduced-size grafts have emerged as solutions.
- Over 50,000 liver transplants have been performed globally.
Purpose:
- To review the evolution and current status of LPLT.
- To highlight challenges and potential improvements in LPLT.
- To emphasize the need for expanded cadaveric liver transplantation (CLT) programs.
Summary:
- CLT primarily treats liver cirrhosis in adults and biliary atresia in children.
- LPLT indications are expanding beyond pediatric cholestatic diseases to include adult conditions like fulminant hepatitis and metabolic disorders.
- Kyoto University reported a 79.5% survival rate in their first 230 LPLT cases, with infection being the primary cause of mortality.
Impact:
- LPLT offers a life-saving option for patients with end-stage liver disease.
- Addressing perioperative infections and ABO incompatibility is crucial for LPLT success.
- Establishing robust CLT programs is essential to meet the growing demand for liver transplantation.