[A comparison of the patterns of delayed cell death after exposure to genotoxic agents]

A lot of data have been provided on different types of cells showing that ionizing radiation induces a hereditable genome instability, which may lead to mutations chromosome aberrations and cell death. In this paper we studied delayed death, proliferative activity, sensitivity to genotoxic agents to progeny of HeLa and LL cells following treatment with ionizing radiation, cis-platinum, methylhydroxurea which induce different types of lesions with different rate of repair. The rate of death of the progeny, dynamics of the clonogen ability recovery, growth rate recovery after the treatment with genotoxic agents are different. We have supposed that the delayed cell death may be associated with different types of hereditable lesions.