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Sucralfate prophylaxis of fluorouracil-induced stomatitis
F Giorgi1, R Bascioni, G De Signoribus
1Oncology Unit, Ospedale Madonna del Soccorso, San Benedetto del Tronto, Italy.
Tumori
|November 1, 1996
Summary
Sucralfate effectively reduced 5-fluorouracil-induced stomatitis in a phase II study. This finding suggests sucralfate may be a viable option for preventing chemotherapy side effects.
Area of Science:
- Oncology
- Pharmacology
Background:
- 5-fluorouracil (5-FU) chemotherapy can cause severe stomatitis, a significant side effect impacting patient quality of life.
- Previous attempts to prevent 5-FU-induced stomatitis have yielded unsatisfactory results.
Purpose of the Study:
- To evaluate the efficacy of sucralfate in reducing and minimizing stomatotoxicity associated with 5-fluorouracil chemotherapy.
Main Methods:
- A phase II study involving 52 patients and 129 chemotherapy cycles was conducted.
- Patients received sucralfate rinses during multiple-day 5-fluorouracil administration.
- Seven patients discontinued sucralfate due to taste intolerance.
Main Results:
- A low incidence of stomatotoxicity was observed.
- Grade 2 stomatitis occurred in 10.8% of cycles (14 cycles).
- Grade 3 stomatitis occurred in 2.3% of cycles (3 cycles).
Conclusions:
- Sucralfate administration shows promise in preventing 5-fluorouracil-induced stomatitis.
- Further research may confirm sucralfate's role in managing chemotherapy-related oral toxicities.