Genes and gene regulation of extracellular matrix proteins: an introduction

Knowledge about the genes that encode extracellular matrix (ECM) proteins is expanding every day. Genes encoding long-known matrix proteins are being isolated while new genes for ECM proteins are being discovered using techniques that directly target the mRNA population. The regulation of expression of most genes occurs through the promoter domain upstream of the coding sequence, although this information may be supplemented by far upstream DNA sequences or DNA in the introns of the gene. Since this important information is embedded in the DNA, the study of gene structure is crucial to the analysis of gene regulation. With all of this new information, it will be possible to characterize common elements in genes that are coordinately regulated, and eventually target individual genes for control by exogenous agents such as drugs.